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Lancet. 1989 Nov 11;2(8672):1115-8.

Cathepsin D: an independent prognostic factor for metastasis of breast cancer.

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  • 1Centre René Huguenin, Saint-Cloud, France.


122 patients with primary breast cancer were followed-up for a median of 4.6 years after surgery. The concentration of cathepsin D in tumour cytosol was strongly related to both metastasis-free survival and disease-free survival and was independent of nine conventional prognostic indices. Cathepsin D assay may prove particularly useful in identifying women who, though without lymph node involvement at presentation, are at high risk of metastatic disease.

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