Frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del in healthy Polish individuals

Int J Immunogenet. 2015 Jun;42(3):195-9. doi: 10.1111/iji.12185. Epub 2015 Mar 1.

Abstract

Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presented by Caucasian populations while it differed significantly when compared to non-European populations, which could be a result of variable selection pressure put upon studied alleles or hindered gene flow between populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles*
  • Gene Frequency*
  • Genetics, Population
  • Genotype
  • Healthy Volunteers*
  • Humans
  • INDEL Mutation*
  • Middle Aged
  • Poland
  • Polymorphism, Single Nucleotide*
  • Receptors, Purinergic P2X7 / genetics*
  • Toll-Like Receptor 2 / genetics*
  • White People / genetics*
  • Young Adult

Substances

  • Receptors, Purinergic P2X7
  • Toll-Like Receptor 2