Abstract
Using modified β-galactosidase covalently linked to cross-linked polyelectrolyte multilayers (PEM), catalytically active materials have been designed. Their enzymatic activity can be modulated, partially in a reversible way, simply by stretching. This strategy, based on enzyme conformational changes, constitutes a new tool for the development of biocatalytic mechano-responsive materials.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biocatalysis
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Biomimetic Materials / chemistry*
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Biomimetic Materials / metabolism
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Biomimetics
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Biotechnology / methods*
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Electrolytes / chemistry
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Electrolytes / metabolism
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Enzyme Activation
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Models, Molecular
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Molecular Conformation
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Polymers / chemistry
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Polymers / metabolism
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beta-Galactosidase / chemistry
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beta-Galactosidase / metabolism*
Substances
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Electrolytes
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Polymers
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beta-Galactosidase