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Localization of a human brain sodium channel gene (SCN2A) to chromosome 2.
Department of Biochemistry, Oregon Health Sciences University, Portland 97201.
A DNA probe derived from a human genomic library has been used to localize on human chromosomes a gene coding for the alpha-subunit of the brain type II sodium channel (SCN2A). Hybridization of the probe to Southern blots made with DNAs from a rodent-human somatic cell hybrid panel indicates localization to the long arm of human chromosome 2. In situ hybridization to metaphase chromosomes confirms this assignment and indicates regional localization to 2q21-q33. The probe also reveals a frequent two-allele HaeIII RFLP.
PMID: 2571571 [PubMed - indexed for MEDLINE]
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Cited by 7 PubMed Central articles
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Use-dependent potentiation of the Nav1.6 sodium channel.
Zhou W, Goldin AL.
Biophys J. 2004 Dec; 87(6):3862-72. Epub 2004 Oct 1.
[Biophys J. 2004]
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Paroxysmal dystonic choreoathetosis: tight linkage to chromosome 2q.
Fink JK, Rainer S, Wilkowski J, Jones SM, Kume A, Hedera P, Albin R, Mathay J, Girbach L, Varvil T, et al.
Am J Hum Genet. 1996 Jul; 59(1):140-5.
[Am J Hum Genet. 1996]
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Targeted gene walking by low stringency polymerase chain reaction: assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31.
Malo MS, Srivastava K, Andresen JM, Chen XN, Korenberg JR, Ingram VM.
Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):2975-9.
[Proc Natl Acad Sci U S A. 1994]
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