[Lipases in catalytic reactions of organic chemistry]

Prikl Biokhim Mikrobiol. 2014 Jul-Aug;50(4):347-73. doi: 10.7868/s0555109914040187.
[Article in Russian]

Abstract

Aspects of enzymatic catalysis in lipase-catalyzed reactions of organic synthesis are discussed in the review. The data on modern methods of protein engineering and enzyme modification allowing a broader range of used substrates are briefly summarized. The application of lipase in the preparation of pharmaceuticals and agrochemicals containing no inactive enantiomers and in the synthesis of secondary alcohol enantiomers and optically active amides is demonstrated. The subject of lipase involvement in the C-C bond formation in the Michael reaction is discussed. Data on the enzymatic synthesis of construction materials--polyesters, siloxanes, etc.--are presented. Examples demonstrating the application of lipase enzymatic catalysis in industry are given.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Biocatalysis
  • Catalytic Domain
  • Chemistry, Organic / methods*
  • Construction Materials
  • Directed Molecular Evolution / methods*
  • Lipase / chemistry*
  • Polyesters / chemical synthesis
  • Protein Engineering
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • Siloxanes / chemical synthesis

Substances

  • Polyesters
  • Siloxanes
  • Lipase