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Cont Lens Anterior Eye. 2015 Jun;38(3):206-10. doi: 10.1016/j.clae.2015.01.007. Epub 2015 Feb 16.

Oral omega-3 fatty acids treatment in computer vision syndrome related dry eye.

Author information

  • 1Laser Eye Clinic, Noida 201301, India. Electronic address: brahul_2371@yahoo.co.in.
  • 2Department of Pathology, Santosh Medical College and Hospital, Ghaziabad 201301, India.
  • 3Department of Ophthalmology, Rotary Eye Hospital, Maranda, Palampur 176102, India.
  • 4Department of Microbiology, Narayan Medical College, Sasaram, India.

Abstract

PURPOSE:

To assess the efficacy of dietary consumption of omega-3 fatty acids (O3FAs) on dry eye symptoms, Schirmer test, tear film break up time (TBUT) and conjunctival impression cytology (CIC) in patients with computer vision syndrome.

SETTING AND DESIGN:

Interventional, randomized, double blind, multi-centric study.

METHODS:

Four hundred and seventy eight symptomatic patients using computers for more than 3h per day for minimum 1 year were randomized into two groups: 220 patients received two capsules of omega-3 fatty acids each containing 180mg eicosapentaenoic acid (EPA) and 120mg docosahexaenoic acid (DHA) daily (O3FA group) and 236 patients received two capsules of a placebo containing olive oil daily for 3 months (placebo group). The primary outcome measure was improvement in dry eye symptoms and secondary outcome measures were improvement in Nelson grade and an increase in Schirmer and TBUT scores at 3 months.

RESULTS:

In the placebo group, before dietary intervention, the mean symptom score, Schirmer, TBUT and CIC scores were 7.5±2, 19.9±4.7mm, 11.5±2s and 1±0.9 respectively, and 3 months later were 6.8±2.2, 20.5±4.7mm, 12±2.2s and 0.9±0.9 respectively. In the O3FA group, these values were 8.0±2.6, 20.1±4.2mm, 11.7±1.6s and 1.2±0.8 before dietary intervention and 3.9±2.2, 21.4±4mm, 15±1.7s, 0.5±0.6 after 3 months of intervention, respectively.

CONCLUSION:

This study demonstrates the beneficial effect of orally administered O3FAs in alleviating dry eye symptoms, decreasing tear evaporation rate and improving Nelson grade in patients suffering from computer vision syndrome related dry eye.

Copyright © 2015 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.

KEYWORDS:

Computer vision syndrome; Dry eye; Goblet cell density; Omega 3 fatty acids (O3FAs); Tear film break up time

PMID:
25697893
[PubMed - indexed for MEDLINE]
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