Abstract
We report the rapid diagnosis of malaria by aptamer-tethered enzyme capture (APTEC) whereby an aptamer captures biomarker Plasmodium falciparum lactate dehydrogenase (PfLDH) then activity is measured colorimetrically. The robust test was sensitive (limit of detection = 4.9 ng mL(-1)) and could reliably diagnose malaria in clinical blood samples.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aptamers, Nucleotide / chemistry
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Aptamers, Nucleotide / metabolism*
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Biomarkers / blood
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Biomarkers / metabolism
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Colorimetry*
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Erythrocytes / metabolism
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Erythrocytes / parasitology
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Humans
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Lactate Dehydrogenases / blood
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Lactate Dehydrogenases / isolation & purification*
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Lactate Dehydrogenases / metabolism
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Malaria / diagnosis*
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Malaria / parasitology
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Malaria / pathology
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Plasmodium falciparum / enzymology*
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Rats
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Sensitivity and Specificity
Substances
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Aptamers, Nucleotide
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Biomarkers
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Lactate Dehydrogenases