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1: Lancet. 1989 Jul 8;2(8654):66-71.Links
Comment in:
Lancet. 1989 Aug 19;2(8660):452.
Lancet. 1989 Sep 2;2(8662):565.

Galactose consumption and metabolism in relation to the risk of ovarian cancer.

Cramer DW, Harlow BL, Willett WC, Welch WR, Bell DA, Scully RE, Ng WG, Knapp RC.

Brigham and Women's Hospital, Obstetrics and Gynecology Epidemiology Center, Boston, Massachusetts 02115.

In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined. Yogurt was consumed at least monthly by 49% of cases and 36% of controls. The mean transferase activity of cases was significantly lower than that of controls. When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1.17 compared with 0.98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio. Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.

PMID: 2567871 [PubMed - indexed for MEDLINE]

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