Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population

Int J Clin Exp Pathol. 2014 Dec 1;7(12):8952-7. eCollection 2014.

Abstract

Objective: To investigate the association of three polymorphisms in the Interleukin-27 (IL-27) gene with CD risk in Chinese population.

Methods: This case-control study involved 312 CD patients and 479 age- and sex-matched healthy controls. Genotyping was performed using PCR-LDR method. Data were analyzed using Haplo. Stats program.

Results: There were significant differences between patients and controls in allele distributions of rs153109 (Pallele = 0.036). The risk for CD associated with the rs153109-G mutant allele was increased by 26% (95% CI [confidence interval]: 1.02-1.56; P = 0.03) under the additive model and by 45% (95% CI: 1.07-1.97; P = 0.02) under the dominant model. In haplotype analysis, haplotype T-T-G (in order of rs17855750, rs181206 and rs153109) increased the odds of CD by 37% (95% CI: 1.04-1.81; P = 0.028).

Conclusions: In conclusion, genetic defects in IL-27 gene showed remarkable associations with CD in Chinese.

Keywords: Crohn’s diseases; IL-27; association study; polymorphism; susceptibility.

MeSH terms

  • Adolescent
  • Adult
  • Asian People / genetics*
  • Case-Control Studies
  • Child
  • Crohn Disease / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Interleukins / genetics*
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Young Adult

Substances

  • Interleukins
  • MYDGF protein, human