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J Occup Environ Med. 2015 Feb;57(2):202-9. doi: 10.1097/JOM.0000000000000337.

Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China.

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  • 1From the Institute of Environmental Medicine (Drs Bigert and Gustavsson), Karolinska Institutet, Stockholm, Sweden; International Agency for Research on Cancer (Drs Straif, Schüz, and Olsson), Lyon, France; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance-Institute of the Ruhr-Universität Bochum (IPA) (Drs Pesch and Brüning, Mr Kendzia), Germany; Inserm, Centre for Research in Epidemiology and Population Health (CESP) (Drs Stücker and Guida), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France; Université Paris-Sud (Drs Stücker and Guida), UMRS 1018, F-94807, Villejuif, France; Institut für Epidemiologie I (Drs Brüske and Wichmann), Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany; Department of Clinical Sciences and Community Health (Dr Pesatori), Università degli Studi di Milano, Milan, Italy; National Cancer Institute (Drs Landi and Caporaso), Bethesda, MD; Division of Occupational and Environmental Health (Drs Tse and Yu), School of Public Health and Primary Care, The Chinese University of Hong Kong, China; Research Centre of University of Montréal Hospital Centre (Drs Siemiatycki and Pintos), University of Montréal, Canada; Cancer Epidemiology Unit (Drs Merletti and Mirabelli), Department of Medical Sciences, University of Turin, Italy; Department of Environmental Medicine and Public Health (Dr Simonato), University of Padua, Italy; Institute for Medical Informatics (Dr Jöckel), Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany; Bremen Institute for Prevention Research and Social Medicine (Drs Ahrens and Pohlabeln), Bremen, Germany; CIBERESP (Dr Tardón), University of Oviedo, Spain; Russian Cancer Research Centre (Dr Zaridze), Moscow, Russia; Roy Castle Lung Cancer Research Programme, Cancer Research Centre (Dr Field), University of Liverpool, UK; Centre for Public Health Research (Drs Mannetje and Pearce), Massey University, Wellingt

Abstract

OBJECTIVES:

To investigate the risk of lung cancer among cooks, while controlling for smoking habits.

METHODS:

We used data from the SYNERGY project including pooled information on lifetime work histories and smoking habits from 16 case-control studies conducted in Europe, Canada, New Zealand, and China.

RESULTS:

Before adjustment for smoking, we observed an increased risk of lung cancer in male cooks, but not in female cooks. After adjusting, there was no increased risk and no significant exposure-response relationship. Nevertheless, subgroup analyses highlighted some possible excess risks of squamous cell carcinoma and small cell carcinoma in female cooks.

CONCLUSIONS:

There is evidence that lung cancer risks among cooks may be confounded by smoking. After adjustment, cooks did not experience an increased risk of lung cancer overall. The subgroup analyses showing some excess risks among female cooks require cautious interpretation.

PMID:
25654522
[PubMed - indexed for MEDLINE]
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