Recurrent HLA-B56 mediated neonatal alloimmune thrombocytopenia with fatal outcomes

Transfus Apher Sci. 2015 Jun;52(3):311-3. doi: 10.1016/j.transci.2015.01.007. Epub 2015 Jan 12.

Abstract

Neonatal alloimmune thrombocytopenia is caused by maternal antibodies against paternally-inherited alloantigens present on foetal platelets and is a significant cause of morbidity and mortality in neonates. While generally thought of as a human platelet antibody mediated phenomenon, cases of HLA mediated NAIT have been reported. We document the investigation of a patient with two pregnancies affected by HLA-B56 mediated NAIT and a proposal for management of future pregnancies.

Keywords: Alloimmune; Fetomaternal; HLA; Neonatal; Thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, Human Platelet / immunology
  • Blood Platelets / immunology
  • Fatal Outcome
  • Female
  • Fetal Death
  • HLA-B Antigens / chemistry*
  • Heterozygote
  • Humans
  • Infant, Newborn
  • Intracranial Hemorrhages
  • Isoantibodies / immunology
  • Male
  • Pedigree
  • Recurrence
  • Thrombocytopenia, Neonatal Alloimmune / blood*
  • Thrombocytopenia, Neonatal Alloimmune / immunology

Substances

  • Antigens, Human Platelet
  • HLA-B Antigens
  • HLA-B56 antigen
  • Isoantibodies