Striking antitumor activity of a methinium system with incorporated quinoxaline unit obtained by spontaneous cyclization

Chembiochem. 2015 Mar 2;16(4):555-8. doi: 10.1002/cbic.201402662. Epub 2015 Jan 28.

Abstract

A novel pentamethinium salt was synthesized with an unforeseen expanded conjugated quinoxaline unit directly incorporated into a pentamethinium chain. The compound exhibited high fluorescence intensity, selective mitochondrial localization, high cytotoxicity, and selectivity toward malignant cell lines, and resulted in remarkable in vivo suppression of tumor growth in mice.

Keywords: cancer; fluorescent probes; methinium salt; mitochondrial localization; quinoxaline; tumor growth suppression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / therapeutic use
  • Cell Line, Tumor
  • Cyclization
  • Hexamethonium / chemistry*
  • Hexamethonium / therapeutic use
  • Mice
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Quinoxalines / chemistry*
  • Quinoxalines / therapeutic use

Substances

  • Antineoplastic Agents
  • Quinoxalines
  • Hexamethonium