Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Transl Med. 2015 Jan 27;13:28. doi: 10.1186/s12967-015-0388-1.

Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice.

Qiu X1,2,3, Fu K4,5, Zhao X6,7, Zhang Y8, Yuan Y9, Zhang S10, Gu X11, Guo H12.

Author information

  • 1Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. Xuefeng_qiu@163.com.
  • 2Institute of Urology, Nanjing University, Nanjing, 210093, China. Xuefeng_qiu@163.com.
  • 3State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China. Xuefeng_qiu@163.com.
  • 4Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. Kaifu1988@yeah.net.
  • 5Institute of Urology, Nanjing University, Nanjing, 210093, China. Kaifu1988@yeah.net.
  • 6Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. dr.zxz@hotmail.com.
  • 7Institute of Urology, Nanjing University, Nanjing, 210093, China. dr.zxz@hotmail.com.
  • 8State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China. zgam90@163.com.
  • 9Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. yuanym6666@163.com.
  • 10Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. zsw999@hotmail.com.
  • 11Department of Anesthesiology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. xiaopinggu1@gmail.com.
  • 12Department of Urology, Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing, 210008, China. dr.guohongqian@gmail.com.

Abstract

Astaxanthin (ATX) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Previous studies have shown that ATX has effects of eliminating oxygen free radicals and can protect organs from ischemia/reperfusion (IR) induced injury. The present study was designed to further investigate the protective effects of ATX on oxidative stress induced toxicity in tubular epithelial cells and on IR induced renal injury in mice. ATX, at a concentration of 250 nM, attenuated 100 μM H2O2-inudced viability decrease of tubular epithelial cells. In vivo, ATX preserved renal function 12 h or 24 h post IR. Pretreatment of ATX via oral gavage for 14 consecutive days prior to IR dramatically prevented IR induced histological damage 24 h post IR. Histological results showed that the pathohistological score, number of apoptotic cells, and the expression of α-smooth muscle actin were significantly decreased by pretreatment of ATX. In addition, oxidative stress and inflammation in kidney samples were significantly reduced by ATX 24 h post IR. Taken together, the current study suggests that pretreatment of ATX is effective in preserving renal function and histology via antioxidant activity.

PMID:
25623758
[PubMed - indexed for MEDLINE]
PMCID:
PMC4323259
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk