Abstract
We investigated the striatal and extrastriatal DAT availability (SPM8) by [(123)I]FP-CIT-SPECT in 15 PD patients with depression and 35 PD patients without depression. A cluster with significant (p < 0.05) lower tracer binding in PD with depression was found in left cingulate cortex, persistent after correction for age, disease severity and duration, and inversely correlated with depression scores (r -0.336, p < 0.05). Our data indicate a significant association between PD depression and cingulate dopaminergic denervation supporting the dopaminergic hypothesis of PD depression.
MeSH terms
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Aged
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Brain Mapping
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Caudate Nucleus / diagnostic imaging
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Caudate Nucleus / metabolism*
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Depressive Disorder / complications
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Depressive Disorder / metabolism
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Dopamine / metabolism
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Gyrus Cinguli / diagnostic imaging
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Gyrus Cinguli / metabolism*
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Humans
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Parkinson Disease / complications
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Parkinson Disease / diagnostic imaging
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Parkinson Disease / metabolism*
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Parkinson Disease / psychology
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Putamen / diagnostic imaging
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Putamen / metabolism*
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Radiopharmaceuticals
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Tomography, Emission-Computed, Single-Photon
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Tropanes
Substances
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Radiopharmaceuticals
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Tropanes
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2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
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Dopamine