Site-selective nucleation and controlled growth of gold nanostructures in tobacco mosaic virus nanotubulars

Small. 2015 Jun 3;11(21):2505-9. doi: 10.1002/smll.201401512. Epub 2015 Jan 22.

Abstract

Site-selective biomineralization of Au nanostructures in the interior channel of Tobacco Mosaic Virus (TMV) is achieved by mutating threonine 103 in TMV to cysteine (T103C-TMV) to introduce the strong coordination interaction between the arrayed sulfhydryl ligands and gold species. By finely tuning the reaction conditions, Au nanoparticle chains and Au nanorods are successfully and exclusively synthesized inside the T103C-TMV nanotubes.

Keywords: biomineralization; chemisorption; controlled synthesis; gold nanostructures; nanotubes; tobacco mosaic virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Capsid Proteins / chemistry
  • Capsid Proteins / genetics
  • Capsid Proteins / ultrastructure
  • Cysteine / chemistry
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / ultrastructure
  • Metal Nanoparticles / virology
  • Microscopy, Electron, Transmission
  • Mutagenesis, Site-Directed
  • Nanotubes / chemistry
  • Nanotubes / ultrastructure
  • Nanotubes / virology
  • Protein Multimerization
  • Tobacco Mosaic Virus / chemistry*
  • Tobacco Mosaic Virus / genetics
  • Tobacco Mosaic Virus / ultrastructure

Substances

  • Capsid Proteins
  • H protein, Tobacco mosaic virus
  • Gold
  • Cysteine