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Mol Gen Mikrobiol Virusol. 1989 Nov;(11):14-20.

[Isolation of recombinant vaccine strains of poliovirus from patients with poliomyelitis].

[Article in Russian]


Oligonucleotide maps of some poliovirus type 2 strains isolated from polio cases, while being clearly related to that of the Sabin vaccine type 2 strain, exhibited, nevertheless, marked differences from the reference (vaccine) map. Several large oligonucleotides derived from 4 such strains were subjected to enzymatic sequencing. The results strongly suggest that all of them were intertypic recombinants between the Sabin strains. The 5'-parts of the genomes of these strains were derived from the type 2 vaccine whereas the 3'-parts were of type 1 (in 2 strains) or type 3 (in other 2 strains) origin.

[PubMed - indexed for MEDLINE]
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