Neuron. 1989 May;2(5):1453-63.

Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.

Source

Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts 02115.

Abstract

The major component of whole-cell Ca2+ current in differentiated, neuron-like rat pheochromocytoma (PC12) cells and sympathetic neurons is carried by dihydropyridine-insensitive, high-threshold-activated N-type Ca2+ channels. We show that these channels have unitary properties distinct from those of previously described Ca2+ channels and contribute both slowly inactivating and large sustained components of whole-cell current. The N-type Ca2+ currents are modulated by GTP binding proteins. The snail toxin omega-conotoxin reveals two pharmacological components of N-type currents, one blocked irreversibly and one inhibited reversibly. Contrary to previous reports, neuronal L-type channels are insensitive to omega-conotoxin. N-type Ca2+ channels appear to be specific for neuronal cells, since their functional expression is greatly enhanced by nerve growth factor.

PMID:: 2560643; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Biophysical and pharmacological characterization of voltage-dependent Ca2+ channels in neurons isolated from rat nucleus accumbens. [J Neurophysiol. 1998]
Biophysical and pharmacological characterization of voltage-dependent Ca2+ channels in neurons isolated from rat nucleus accumbens.
Churchill D, Macvicar BA. J Neurophysiol. 1998 Feb; 79(2):635-47.
Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein. [J Neurosci. 1993]
Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein.
Haws CM, Slesinger PA, Lansman JB. J Neurosci. 1993 Mar; 13(3):1148-56.
Mu-opioid and GABA(B) receptors modulate different types of Ca2+ currents in rat nodose ganglion neurons. [Neuroscience. 1998]
Mu-opioid and GABA(B) receptors modulate different types of Ca2+ currents in rat nodose ganglion neurons.
Rusin KI, Moises HC. Neuroscience. 1998 Aug; 85(3):939-56.
Review Modulation of Ca2+-channel currents in sensory neurons by pertussis toxin-sensitive G-proteins. [Ann N Y Acad Sci. 1989]
Review Modulation of Ca2+-channel currents in sensory neurons by pertussis toxin-sensitive G-proteins.
Dolphin AC, Scott RH. Ann N Y Acad Sci. 1989; 560:387-90.
Review Direct G-protein regulation of Ca2+ channels. [Ann N Y Acad Sci. 1989]
Review Direct G-protein regulation of Ca2+ channels.
Brown AM, Yatani A, Imoto Y, Codina J, Mattera R, Birnbaumer L. Ann N Y Acad Sci. 1989; 560:373-86.

See reviews... See all...

Cited by over 100 PubMed Central articles

AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels. [J Neurosci. 2011]
AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
Zhang J, Bal M, Bierbower S, Zaika O, Shapiro MS. J Neurosci. 2011 May 11; 31(19):7199-211.
FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni. [PLoS Negl Trop Dis. 2010]
FMRFamide-like peptides (FLPs) enhance voltage-gated calcium currents to elicit muscle contraction in the human parasite Schistosoma mansoni.
Novozhilova E, Kimber MJ, Qian H, McVeigh P, Robertson AP, Zamanian M, Maule AG, Day TA. PLoS Negl Trop Dis. 2010 Aug 10; 4(8):e790. Epub 2010 Aug 10.
Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels. [J Biol Chem. 2010]
Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels.
Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M, et al. J Biol Chem. 2010 Jul 9; 285(28):21750-67. Epub 2010 May 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Elementary properties and pharmacological sensitivities of calcium channels in m...
Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.
Neuron. 1989 May ;2(5):1453-63.

PubMed
Effects of tetrahydrocannabinol content on marijuana smoking behavior, subjectiv...
Effects of tetrahydrocannabinol content on marijuana smoking behavior, subjective reports, and performance.
Pharmacol Biochem Behav. 1989 Sep ;34(1):173-9.

PubMed
The development of new antileukotriene drugs: specific leukotriene D4 antagonist...
The development of new antileukotriene drugs: specific leukotriene D4 antagonists and 5-lipoxygenase inhibitors.
Adv Exp Med Biol. 1989 ;259:75-108.

PubMed
Treatment of pigmented villonodular synovitis of the knee with yttrium-90 silica...
Treatment of pigmented villonodular synovitis of the knee with yttrium-90 silicate: prospective evaluations by arthroscopy, histology, and 99mTc pertechnetate uptake measurements.
Ann Rheum Dis. 1989 Dec ;48(12):1007-13.

PubMed
Epinephrine and dDAVP administration in patients with congenital nephrogenic dia...
Epinephrine and dDAVP administration in patients with congenital nephrogenic diabetes insipidus. Evidence for a pre-cyclic AMP V2 receptor defective mechanism.
Kidney Int. 1989 Nov ;36(5):859-66.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information