Abstract
We report a facile synthesis of bifunctional Fe3O4-Ag(125)I heterodimers for use as dual-modality imaging agents in magnetic resonance (MR) and single-photon emission computed tomography (SPECT). We introduced (125)I, which is a clinically used radioisotope, as a SPECT reporter, into Fe3O4-Ag heterodimer nanoparticles to provide a new type of bifunctional contrast agent for MRI and SPECT imaging.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Contrast Media / chemistry
-
Dimerization
-
Gold / chemistry
-
HeLa Cells
-
Human Umbilical Vein Endothelial Cells
-
Humans
-
Iodine Radioisotopes / therapeutic use*
-
Iron / chemistry
-
Liver / diagnostic imaging
-
Magnetic Resonance Imaging / methods*
-
Magnetite Nanoparticles / chemistry*
-
Mice
-
Microscopy, Electron, Transmission
-
Nanotechnology / methods*
-
Phantoms, Imaging
-
Radioisotopes / chemistry
-
Spleen / diagnostic imaging
-
Tomography, Emission-Computed, Single-Photon / methods*
-
X-Ray Diffraction
Substances
-
Contrast Media
-
Iodine Radioisotopes
-
Magnetite Nanoparticles
-
Radioisotopes
-
Gold
-
Iron