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Fertil Steril. 2015 Mar;103(3):749-55.e2. doi: 10.1016/j.fertnstert.2014.12.104. Epub 2015 Jan 7.

Soy food intake and treatment outcomes of women undergoing assisted reproductive technology.

Author information

  • 1School of Medicine, Pontificia Universidad Javeriana, Bogota, Colombia.
  • 2Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
  • 3Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
  • 4Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.
  • 5Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • 6Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • 7Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: jchavarr@hsph.harvard.edu.

Abstract

OBJECTIVE:

To study the relation of dietary phytoestrogens intake and clinical outcomes of women undergoing infertility treatment with the use of assisted reproductive technology (ART).

DESIGN:

Prospective cohort study.

SETTING:

Fertility center.

PATIENT(S):

A total of 315 women who collectively underwent 520 ART cycles from 2007 to 2013.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Implantation, clinical pregnancy, and live birth rates per initiated cycle.

RESULT(S):

Soy isoflavones intake was positively related to live birth rates in ART. Compared with women who did not consume soy isoflavones, the multivariable-adjusted odds ratios of live birth (95% confidence interval) for women in increasing categories of soy isoflavones intake were 1.32 (0.76-2.27) for women consuming 0.54-2.63 mg/d, 1.87 (1.12-3.14) for women consuming 2.64-7.55 mg/d, and 1.77 (1.03-3.03) for women consuming 7.56-27.89 mg/d.

CONCLUSION(S):

Dietary soy intake was positively related to the probability of having a live birth during infertility treatment with ART.

Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Cohort studies; assisted reproductive techniques; isoflavones; phytoestrogens; soy foods

PMID:
25577465
[PubMed - indexed for MEDLINE]
PMCID:
PMC4346414
Free PMC Article
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