Abstract
Particle sorting using acoustofluidics has enormous potential but widespread adoption has been limited by complex device designs and low throughput. Here, we report high-throughput separation of particles and T lymphocytes (600 μL min(-1)) by altering the net sonic velocity to reposition acoustic pressure nodes in a simple two-channel device. The approach is generalizable to other microfluidic platforms for rapid, high-throughput analysis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acoustics* / instrumentation
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Cell Separation / instrumentation
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Cell Separation / methods*
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High-Throughput Screening Assays / instrumentation
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High-Throughput Screening Assays / methods*
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Humans
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Hydrostatic Pressure
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Microfluidic Analytical Techniques / instrumentation
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Microfluidic Analytical Techniques / methods*
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Particle Size
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T-Lymphocytes / cytology*