A survey of infectious disease clinical practices among pediatric blood and marrow transplant programs in the United States

Pediatr Blood Cancer. 2015 Apr;62(4):731-5. doi: 10.1002/pbc.25355. Epub 2015 Jan 3.

Abstract

We assessed clinical practice standards for infectious complications among pediatric blood and marrow transplant (PBMT) recipients. An anonymous online survey was sent to all 64 pediatric program directors (PD) of PBMT centers in the United States, which are accredited by the Foundation for the Accreditation of Cellular Therapy (FACT). The overall response rate was 56% (CI: 44-68%); variations in clinical practices were noted regarding (i) surveillance for late onset cytomegalovirus (CMV) infection and (ii) pharmacokinetic/therapeutic drug monitoring of antimicrobials. Prospective studies among PBMT recipients to address infectious complications among this population and variations in clinical practice may be required.

Keywords: BMT; FACT; Infectious diseases; Pediatrics; Voriconazole.

MeSH terms

  • Accreditation
  • Adolescent
  • Anti-Infective Agents / therapeutic use
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Communicable Disease Control
  • Communicable Diseases / epidemiology*
  • Cross Infection / epidemiology*
  • Cross Infection / prevention & control
  • Cytomegalovirus Infections / epidemiology*
  • Cytomegalovirus Infections / prevention & control
  • Data Collection
  • Female
  • Hospitals, Special*
  • Humans
  • Male
  • United States / epidemiology

Substances

  • Anti-Infective Agents