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    FEBS Lett. 1989 Nov 6;257(2):439-42.

    Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene.

    Ushkaryov YuA, Monastyrskaya GS, Broude NE, Nikiforova NN, Bessarab DA, Orlova MYu, Petrukhin KE, Modyanov NN, Sverdlov ED.

    Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.

    The existence of a chromosome gene family containing at least one gene and one pseudogene was shown for the Na+,K+-ATPase beta-subunit. A partial structure of the beta 1-gene was determined, the coding part of which was completely homologous to cDNA of the Na+,K+-ATPase beta I-subunit from HeLa cells. The region encoding the putative protein transmembrane domain was shown to be bordered by two introns. The structure of a pseudogene (beta psi) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the beta I-subunit cDNA from HeLa cells is about 88%.

    PMID: 2555225 [PubMed - indexed for MEDLINE]

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