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FEBS Lett. 1989 Nov 6;257(2):439-42.

Human Na+,K+-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene.

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  • 1Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, Moscow.


The existence of a chromosome gene family containing at least one gene and one pseudogene was shown for the Na+,K+-ATPase beta-subunit. A partial structure of the beta 1-gene was determined, the coding part of which was completely homologous to cDNA of the Na+,K+-ATPase beta I-subunit from HeLa cells. The region encoding the putative protein transmembrane domain was shown to be bordered by two introns. The structure of a pseudogene (beta psi) was determined. This pseudogene is processed and contains multiple stop codons. Its homology to the beta I-subunit cDNA from HeLa cells is about 88%.

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