Abstract
A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells.
Keywords:
ESIPT; aggregation-induced emission; bacteria; fluorescent probes; photodynamic therapy.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacteria* / drug effects
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Bacteria* / radiation effects
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Cell Shape / drug effects
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Cell Shape / radiation effects
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Fluorescent Dyes* / chemistry
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Fluorescent Dyes* / pharmacology
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Humans
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Jurkat Cells
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K562 Cells
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Microbial Viability* / drug effects
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Microbial Viability* / radiation effects
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Molecular Probes* / chemistry
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Molecular Probes* / pharmacology
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Optical Imaging / methods*
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology
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Photochemotherapy / methods*
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Photosensitizing Agents* / chemistry
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Photosensitizing Agents* / pharmacology
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Picolinic Acids / chemistry
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Picolinic Acids / pharmacology
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Spectrometry, Fluorescence
Substances
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Fluorescent Dyes
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Molecular Probes
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Organometallic Compounds
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Photosensitizing Agents
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Picolinic Acids
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bis-dipicolylamine-Zinc(II)