A multifunctional probe with aggregation-induced emission characteristics for selective fluorescence imaging and photodynamic killing of bacteria over mammalian cells

Adv Healthc Mater. 2015 Apr 2;4(5):659-63. doi: 10.1002/adhm.201400654. Epub 2014 Dec 22.

Abstract

A multifunctional probe aggregation-induced emission-Zinc(II)-dipicolylamine (AIE-ZnDPA) is developed for selective targeting, fluorescence imaging, and photodynamic killing of both Gram-positive and Gram-negative bacteria over mammalian cells. The probe has significant advantages in simple probe design, enhanced fluorescence upon bacteria binding, excellent photostability, and broad-spectrum antibacterial activity with almost no harm to mammalian cells.

Keywords: ESIPT; aggregation-induced emission; bacteria; fluorescent probes; photodynamic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria* / drug effects
  • Bacteria* / radiation effects
  • Cell Shape / drug effects
  • Cell Shape / radiation effects
  • Fluorescent Dyes* / chemistry
  • Fluorescent Dyes* / pharmacology
  • Humans
  • Jurkat Cells
  • K562 Cells
  • Microbial Viability* / drug effects
  • Microbial Viability* / radiation effects
  • Molecular Probes* / chemistry
  • Molecular Probes* / pharmacology
  • Optical Imaging / methods*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology
  • Photochemotherapy / methods*
  • Photosensitizing Agents* / chemistry
  • Photosensitizing Agents* / pharmacology
  • Picolinic Acids / chemistry
  • Picolinic Acids / pharmacology
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Molecular Probes
  • Organometallic Compounds
  • Photosensitizing Agents
  • Picolinic Acids
  • bis-dipicolylamine-Zinc(II)