Microbial bile acid metabolic clusters: the bouncers at the bar

Cell Host Microbe. 2014 Nov 12;16(5):551-2. doi: 10.1016/j.chom.2014.10.015. Epub 2014 Nov 12.

Abstract

Colonization resistance refers to the ability of the colonic microbiota to prevent invasion by pathogens including Clostridium difficile. In a recent article, Buffie et al. (2014) have demonstrated that a single metabolic cluster present in the normal, colonic microflora is responsible for preventing C. difficile invasion of healthy hosts.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Bile Acids and Salts / metabolism*
  • Clostridioides difficile / physiology*
  • Disease Susceptibility / microbiology*
  • Female
  • Humans
  • Intestinal Mucosa / metabolism*
  • Intestines / microbiology*
  • Microbiota / physiology*

Substances

  • Bile Acids and Salts