Jpn J Cancer Res. 1989 Jul;80(7):643-8.

A case of leiomyosarcoma associated with humoral hypercalcemia of malignancy: demonstration of biological and immunological activities of parathyroid hormone-related protein in the tumor extract.

Nagata N, Takeda J, Kugai N, Kimoto H, Tomimatsu S, Takatani O, Suzuki K, Fuse Y, Tsuchihashi T, Yamaguchi K, et al.

Source

Third Department of Internal Medicine, National Defense Medical College, Saitama.

Abstract

Hypercalcemia occurred in a patient with leiomyosarcoma when multiple lung metastases developed. Despite normal plasma parathyroid hormone (PTH) levels and low 1,25-dihydroxyvitamin D, this hypercalcemic patient had a marked hypercalciuria and phosphaturia associated with an increased excretion of nephrogenous cyclic AMP (NcAMP). Administration of cisplatin ameliorated both the hypercalcemia and hypercalciuria without any reduction in tumor size of NcAMP excretion. Terminally, acute pancreatitis occurred producing a profound hypocalcemia. In the extract of tumor tissue obtained post mortem, bioactivity stimulating the generation of cyclic AMP in osteogenic cells was demonstrated along with the immunoreactive PTH-related protein (PTH-rP). the first report of a solid non-epithelial malignancy producing PTH-rP and associated with humoral hypercalcemia of malignancy. The hypercalcemia in this case caused acute pancreatitis, which led to a profound hypocalcemia.

PMID:: 2551869; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Parathyroid hormone-related protein as a cause of hypercalcemia in a B-cell type malignant lymphoma. [Intern Med. 1992]
Parathyroid hormone-related protein as a cause of hypercalcemia in a B-cell type malignant lymphoma.
Wada S, Kitamura H, Matsuura Y, Katayama Y, Ohkawa H, Kugai N, Motoyoshi K, Fuse Y, Nagata N. Intern Med. 1992 Aug; 31(8):968-72.
Parathyroid hormone-related protein and transforming growth factor activities in an extract from a breast cancer associated with humoral hypercalcemia of malignancy. [Jpn J Clin Oncol. 1989]
Parathyroid hormone-related protein and transforming growth factor activities in an extract from a breast cancer associated with humoral hypercalcemia of malignancy.
Nagata N, Yasutomo Y, Kugai N, Matsuura Y, Akatsu T, Sugiyama K, Kinoshita T, Takatani O, Mamiya Y, Yamaguchi K. Jpn J Clin Oncol. 1989 Dec; 19(4):353-9.
Recurrent hypercalcemia due to ectopic production of parathyroid hormone-related protein and intact parathyroid hormone in a single patient with multiple malignancies. [Endocr Pract. 2004]
Recurrent hypercalcemia due to ectopic production of parathyroid hormone-related protein and intact parathyroid hormone in a single patient with multiple malignancies.
Eid W, Wheeler TM, Sharma MD. Endocr Pract. 2004 Mar-Apr; 10(2):125-8.
Review Parathyroid hormone-related protein and hypercalcemia. [Cancer. 1997]
Review Parathyroid hormone-related protein and hypercalcemia.
Rankin W, Grill V, Martin TJ. Cancer. 1997 Oct 15; 80(8 Suppl):1564-71.
Review The humoral hypercalcemia of benignancy. A newly appreciated syndrome. [Am J Clin Pathol. 1996]
Review The humoral hypercalcemia of benignancy. A newly appreciated syndrome.
Knecht TP, Behling CA, Burton DW, Glass CK, Deftos LJ. Am J Clin Pathol. 1996 Apr; 105(4):487-92.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

A case of leiomyosarcoma associated with humoral hypercalcemia of malignancy: de...
A case of leiomyosarcoma associated with humoral hypercalcemia of malignancy: demonstration of biological and immunological activities of parathyroid hormone-related protein in the tumor extract.
Jpn J Cancer Res. 1989 Jul ;80(7):643-8.

PubMed
Isolation from human cerebrospinal fluid of a new insulin-like growth factor-bin...
Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II.
FEBS Lett. 1989 Sep 25 ;255(2):253-8.

PubMed
Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potent...
Peroxidase-dependent metabolism of benzene's phenolic metabolites and its potential role in benzene toxicity and carcinogenicity.
Environ Health Perspect. 1989 Jul ;82:23-9.

PubMed
Biochemical contribution to diagnosis and study of a new case of D-glyceric acid...
Biochemical contribution to diagnosis and study of a new case of D-glyceric acidemia/aciduria.
Clin Chem. 1989 Oct ;35(10):2148-51.

PubMed
Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid le...
Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid levels of ir-beta-endorphin, ACTH, cortisol, norepinephrine and glucose in the conscious dog.
Brain Res. 1989 Sep 25 ;498(1):89-98.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A case of leiomyosarcoma associated with humoral hypercalcemia of malignancy: demonstration of biological and immunological activities of parathyroid hormone-related protein in the tumor extract.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information