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Alzheimers Dement. 2015 Jun;11(6):710-7. doi: 10.1016/j.jalz.2014.10.008. Epub 2014 Dec 12.

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.

Author information

  • 1Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address:
  • 2National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • 3Department of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • 4Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • 5Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • 6Department of Neurology, Mayo Clinic, Rochester, MN, USA.
  • 7Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA.
  • 8Department of Pathology, University of Washington, Seattle, WA, USA.
  • 9Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA.
  • 10Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
  • 11Departments of Pathology and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
  • 12Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • 13Department of Physiology, University of Kentucky, Lexington, KY, USA.
  • 14Departments of Neurological Surgery and Neurology, Washington University, St Louis, St Louis, MO, USA.
  • 15Department of Physiology, University of Southern California, Los Angeles, CA, USA.
  • 16Independent Science Writer, Elverson, PA, USA.
  • 17National Institute of Heart, Lung and Blood, National Institutes of Health, Bethesda, MD, USA.
  • 18Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.


Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.

Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.


Alzheimer's disease; Animal models; Biomarkers; Dementia; Small vessel disease; Vascular dementia

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