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Nature. 1989 Sep 21;341(6239):197-205.

Inositol phosphates and cell signalling.

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  • 1AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, Cambridge, UK.


Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.

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