Abstract
Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administered preventively but they are unable to inhibit the epileptogenic effects induced by DTXI and 4-AP which were thought to block the same K+ channel which is blocked by MCD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Aminopyridine
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Aminopyridines / pharmacology*
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Animals
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Elapid Venoms / pharmacology*
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Injections, Intraventricular
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Male
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Neurotoxins / pharmacology*
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Peptides / pharmacology*
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Potassium Channels / classification
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Potassium Channels / drug effects
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Potassium Channels / physiology*
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Rats
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Rats, Inbred Strains
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Seizures / chemically induced
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Seizures / metabolism*
Substances
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Aminopyridines
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Elapid Venoms
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Neurotoxins
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Peptides
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Potassium Channels
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mast cell degranulating peptide
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dendrotoxin
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4-Aminopyridine