Subtypes of K+ channels differentiated by the effect of K+ channel openers upon K+ channel blocker-induced seizures

Brain Res. 1989 Aug 21;495(1):189-92. doi: 10.1016/0006-8993(89)91236-5.

Abstract

Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administered preventively but they are unable to inhibit the epileptogenic effects induced by DTXI and 4-AP which were thought to block the same K+ channel which is blocked by MCD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminopyridine
  • Aminopyridines / pharmacology*
  • Animals
  • Elapid Venoms / pharmacology*
  • Injections, Intraventricular
  • Male
  • Neurotoxins / pharmacology*
  • Peptides / pharmacology*
  • Potassium Channels / classification
  • Potassium Channels / drug effects
  • Potassium Channels / physiology*
  • Rats
  • Rats, Inbred Strains
  • Seizures / chemically induced
  • Seizures / metabolism*

Substances

  • Aminopyridines
  • Elapid Venoms
  • Neurotoxins
  • Peptides
  • Potassium Channels
  • mast cell degranulating peptide
  • dendrotoxin
  • 4-Aminopyridine