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Eur J Pharmacol. 1989 Jun 8;165(1):155-9.

Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice.

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  • 1Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, New York, NY 10035.


Metaphit induces audiogenic seizures in mice. The most severe clonic/tonic seizures occur 18-24 h after metaphit administration. After 48 h the incidence of the seizure episodes begin to diminish. These audiogenic seizures can be prevented by the administration of either PCP or MK-801 24 h after metaphit and 30 min prior to audio stimulation. These seizures may be due to a modulation of the PCP recognition site by metaphit which results in an enhanced probability that the NMDA/PCP ion channels are open.

[PubMed - indexed for MEDLINE]
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