J Neural Transm. 1989;77(2-3):231-6.

[3H]MK-801 binding sites in postmortem brain regions of schizophrenic patients.

Kornhuber J, Mack-Burkhardt F, Riederer P, Hebenstreit GF, Reynolds GP, Andrews HB, Beckmann H.

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Department of Psychiatry, University of Würzburg, Federal Republic of Germany.

Abstract

[3H]MK-801 binding was used as a marker for the NMDA receptorion channel complex in postmortem brain samples from the frontal cortex, hippocampus, putamen, entorhinal region, and amygdala of schizophrenic patients and controls. In schizophrenia [3H]MK-801 binding levels were increased in all brain regions investigated reaching significance in the putamen.

PMID:: 2547892; [PubMed - indexed for MEDLINE]

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