Orbital immunoglobulin IgG4-related inflammatory fibrosclerosing lesion treated with pentoxifylline and α-tocopherol: case report

Br J Oral Maxillofac Surg. 2015 Feb;53(2):197-9. doi: 10.1016/j.bjoms.2014.11.003. Epub 2014 Nov 24.

Abstract

Immunoglobulin G4 (IgG4)-related disease is a distinct group of disorders that are characterised by intense infiltration of an organ with IgG4(+) cells, subsequent inflammation, fibrosis, and masses. We report a new treatment of orbital IgG4-related disease with pentoxyphylline and α-tocopherol, both of which are anti-inflammatory and antifibrotic agents.

Keywords: Fibrosclerotic; IgG(4); Orbital; Pentoxifylline; Vitamin E; α-Tocopherol.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Autoimmune Diseases / drug therapy*
  • B-Lymphocytes / pathology
  • Eosinophils / pathology
  • Female
  • Fibroblasts / pathology
  • Fibrosis
  • Free Radical Scavengers / therapeutic use
  • Humans
  • Immunoglobulin G / drug effects*
  • Lymphocytes / pathology
  • Orbital Diseases / drug therapy*
  • Orbital Pseudotumor / drug therapy
  • Pentoxifylline / therapeutic use*
  • Plasma Cells / pathology
  • Sclerosis
  • T-Lymphocytes / pathology
  • alpha-Tocopherol / therapeutic use*

Substances

  • Anti-Inflammatory Agents
  • Antioxidants
  • Free Radical Scavengers
  • Immunoglobulin G
  • alpha-Tocopherol
  • Pentoxifylline