Abstract
Immunoglobulin G4 (IgG4)-related disease is a distinct group of disorders that are characterised by intense infiltration of an organ with IgG4(+) cells, subsequent inflammation, fibrosis, and masses. We report a new treatment of orbital IgG4-related disease with pentoxyphylline and α-tocopherol, both of which are anti-inflammatory and antifibrotic agents.
Keywords:
Fibrosclerotic; IgG(4); Orbital; Pentoxifylline; Vitamin E; α-Tocopherol.
Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
MeSH terms
-
Adult
-
Anti-Inflammatory Agents / therapeutic use*
-
Antioxidants / therapeutic use*
-
Autoimmune Diseases / drug therapy*
-
B-Lymphocytes / pathology
-
Eosinophils / pathology
-
Female
-
Fibroblasts / pathology
-
Fibrosis
-
Free Radical Scavengers / therapeutic use
-
Humans
-
Immunoglobulin G / drug effects*
-
Lymphocytes / pathology
-
Orbital Diseases / drug therapy*
-
Orbital Pseudotumor / drug therapy
-
Pentoxifylline / therapeutic use*
-
Plasma Cells / pathology
-
Sclerosis
-
T-Lymphocytes / pathology
-
alpha-Tocopherol / therapeutic use*
Substances
-
Anti-Inflammatory Agents
-
Antioxidants
-
Free Radical Scavengers
-
Immunoglobulin G
-
alpha-Tocopherol
-
Pentoxifylline