Within-person variability of urinary bisphenol-A in postmenopausal women

Environ Res. 2014 Nov:135:285-8. doi: 10.1016/j.envres.2014.09.016. Epub 2014 Oct 14.

Abstract

We evaluated the within-person variability of urinary BPA levels over two samples collected three years apart in 90 Women's Health Initiative participants. The intraclass correlation coefficient was 0.09 (95% CI 0.01-0.44), indicating high within-participant variability relative to the between-person variation. Concordance of BPA quartile over time was low (31.7%) and was unrelated to demographic, behavioral, or dietary factors. A single, or even several, measurements of BPA may not adequately classify long-term exposure in human studies.

Keywords: Bisphenol-A; Exposure measurement; Postmenopausal; Variability; Women.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Factors
  • Aged
  • Benzhydryl Compounds / urine*
  • Body Mass Index
  • Diet
  • Environmental Monitoring / methods
  • Environmental Monitoring / statistics & numerical data*
  • Female
  • Humans
  • Middle Aged
  • Phenols / urine*
  • Reproducibility of Results
  • United States

Substances

  • Benzhydryl Compounds
  • Phenols
  • bisphenol A