[Microbicides for preventing sexually transmitted infections: Current status and strategies for preclinical evaluation of new candidates]

José A Fernández Romero; Pedro I Gil; Viviana Ré; Melissa Robbiani; Gabriela Paglini

doi:10.1016/S0325-7541(14)70080-X

[Microbicides for preventing sexually transmitted infections: Current status and strategies for preclinical evaluation of new candidates]

Rev Argent Microbiol. 2014 Jul-Sep;46(3):256-68. doi: 10.1016/S0325-7541(14)70080-X. Epub 2014 Oct 15.

[Article in Spanish]

Authors

José A Fernández Romero¹, Pedro I Gil², Viviana Ré², Melissa Robbiani³, Gabriela Paglini⁴

Affiliations

¹ Center for Biomedical Research, Population Council, Nueva York, Nueva York, EE. UU; Instituto de Virología "Dr. J.M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
² Instituto de Virología "Dr. J.M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
³ Center for Biomedical Research, Population Council, Nueva York, Nueva York, EE. UU.
⁴ Instituto de Virología "Dr. J.M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: gpaglini@immf.uncor.edu.

PMID: 25444135
DOI: 10.1016/S0325-7541(14)70080-X

Abstract

Microbicides are a new tool, still under investigation, which could help prevent infection by the human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). Increasing evidence shows that the complexity of sexual transmission of viral pathogens requires the identification of compounds able to block the early events during the cycle of viral infection. In this manuscript we provide a comprehensive review of the different microbicide strategies that have been studied or are currently being considered for STI prevention, particularly emphasizing those having the potential to block HIV infection. The manuscript also reviews the complex process that is required to conduct future clinical studies in humans and concludes with a brief discussion of the strategies that could be part of the immediate future in microbicide research.

Keywords: Antiviral; Antivirales; HIV; HPV; HSV-2; Microbicidas; Microbicides.

Publication types

English Abstract
Review

MeSH terms

Administration, Intravaginal
Administration, Rectal
Animals
Anti-Infective Agents, Local / chemistry
Anti-Infective Agents, Local / classification
Anti-Infective Agents, Local / isolation & purification
Anti-Infective Agents, Local / pharmacology*
Anti-Infective Agents, Local / toxicity
Clinical Trials as Topic
Disease Models, Animal
Drug Approval
Drug Evaluation, Preclinical / methods*
Enzyme Inhibitors / pharmacology
Female
HIV Infections / prevention & control
HIV Infections / transmission
Herpes Genitalis / prevention & control
Herpes Genitalis / transmission
Humans
Male
Multicenter Studies as Topic
Papillomavirus Infections / prevention & control
Papillomavirus Infections / transmission
Sexually Transmitted Diseases, Bacterial / prevention & control*
Sexually Transmitted Diseases, Viral / prevention & control*
Surface-Active Agents / pharmacology
Technology, Pharmaceutical / methods
Viral Proteins / antagonists & inhibitors
Virus Internalization / drug effects

Substances

Anti-Infective Agents, Local
Enzyme Inhibitors
Surface-Active Agents
Viral Proteins