In the beginning: a personal reminiscence on the origin and legacy of ClC-0, the 'Torpedo Cl(-) channel'

J Physiol. 2015 Sep 15;593(18):4085-90. doi: 10.1113/jphysiol.2014.286260. Epub 2015 Jan 5.

Abstract

This unapologetically subjective essay recalls the Torpedo Cl(-) channel in the years when it had neither a molecular identity nor proper name (ClC-0), and membership in a large superfamily. I discuss the circumstances surrounding its discovery and subsequent research through the 1980s that revealed its unusual molecular architecture and other strange mechanistic characteristics.

Publication types

  • Review

MeSH terms

  • Animals
  • Chloride Channels / metabolism*
  • Chlorides / metabolism*
  • Humans
  • Ion Channel Gating / physiology
  • Torpedo / metabolism*

Substances

  • CLC-1 channel
  • Chloride Channels
  • Chlorides