Synthesis of chiral chalcone derivatives catalyzed by the chiral cinchona alkaloid squaramide

Molecules. 2014 Nov 25;19(12):19491-500. doi: 10.3390/molecules191219491.

Abstract

An effective method has been developed for the preparation of novel chiral chalcone derivatives under mild conditions from the easily accessible starting materials nitromethane and chalcone derivatives 2. The corresponding products were obtained in moderate yields with excellent enantioselectivities (up to 99%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Chalcone / chemical synthesis*
  • Chalcone / chemistry*
  • Cinchona Alkaloids / chemistry*
  • Stereoisomerism

Substances

  • Cinchona Alkaloids
  • Chalcone