Send to:

Choose Destination
See comment in PubMed Commons below
Isr J Med Sci. 1989 Mar;25(3):142-5.

Folic acid deficiency, megaloblastic anemia and peripheral polyneuropathy due to oral contraceptives.

Author information

  • 1Department of Hematology, Assaf Harofeh Medical Center, Zerifin, Israel.


A 34-year-old woman developed megaloblastic anemia and peripheral polyneuropathy following the use of oral contraceptives for 4 years. Low levels of folic acid and vitamin B12 were found. Both the complete recovery after therapy with the vitamins, and the absence of other causes of vitamin B12 and folate deficiency, suggest that the vitamin deficiencies were caused by the oral contraceptives and resulted in the rare combination of megaloblastic anemia and polyneuropathy. The poor response to vitamin B12 alone, and the development of anemia and polyneuropathy 4 months after cessation of vitamin B12 therapy suggest that folate deficiency was the primary problem.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk