Early haemoperfusion with continuous venovenous haemofiltration improves survival of acute paraquat-poisoned patients

J Int Med Res. 2015 Feb;43(1):26-32. doi: 10.1177/0300060514549782. Epub 2014 Nov 12.

Abstract

Objective: To determine whether haemoperfusion (HP) with continuous venovenous haemofiltration (CVVH) improves the survival of patients with acute paraquat poisoning, compared with those treated using HP alone.

Methods: Medical records of patients with acute paraquat poisoning were analysed. Patients were randomised to undergo HP or HP + CVVH within 24 h of paraquat ingestion. Mortality rate, survival duration and cause of death were recorded.

Results: There were no significant differences in mortality rate between the HP group (n = 458) and the HP + CVVH group (n = 226) (57.4% and 58.4%, respectively). The mean survival duration was significantly longer in the HP + CVVH group than the HP group (8.6 ± 3.1 and 5.1 ± 2.3 days, respectively). Early circulatory collapse was a major cause of death in the HP group. The major cause of death in the HP + CVVH group was late respiratory failure.

Conclusion: Combined therapy with HP and CVVH can prevent early death and prolong survival duration following acute paraquat poisoning, providing the opportunity for further treatment.

Keywords: Continuous venovenous haemofiltration; haemoperfusion; paraquat poisoning.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Demography
  • Female
  • Hemofiltration*
  • Hemoperfusion*
  • Humans
  • Male
  • Middle Aged
  • Paraquat / poisoning*
  • Survival Analysis
  • Treatment Outcome
  • Young Adult

Substances

  • Paraquat