Abstract
An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP- and phorbol ester-inducible transcription of the human proenkephalin gene. We report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Base Sequence
-
Cyclic AMP / genetics
-
Cyclic AMP / metabolism*
-
DNA / analysis
-
DNA-Binding Proteins / genetics
-
Deoxyribonuclease I
-
Enhancer Elements, Genetic / drug effects*
-
Enkephalins / genetics*
-
Enkephalins / metabolism
-
Humans
-
Mutation
-
Phorbol Esters / pharmacology*
-
Promoter Regions, Genetic*
-
Protein Precursors / genetics*
-
Protein Precursors / metabolism
Substances
-
DNA-Binding Proteins
-
Enkephalins
-
Phorbol Esters
-
Protein Precursors
-
proenkephalin
-
DNA
-
Cyclic AMP
-
Deoxyribonuclease I