Abstract
A dual-responsive drug delivery system simulating an AND logic gate is developed by core-cross-linking of a disulfide-containing anticancer prodrug with Cu(2+) for safe and efficient delivery of anticancer drugs. These prodrug nanoparticles are stable and exhibit nearly no premature drug release, and allow a fast drug release under simulated intracellular conditions, realizing a precise drug delivery towards cell nuclei.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / toxicity
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Cell Nucleus / metabolism
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Cell Survival / drug effects
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Copper / chemistry
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Doxorubicin / chemistry
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Doxorubicin / toxicity
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Drug Carriers / chemistry*
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HeLa Cells
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Humans
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Hydrogen-Ion Concentration
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Nanoparticles / chemistry*
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Polyethylene Glycols / chemistry
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Prodrugs / chemistry*
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Prodrugs / toxicity
Substances
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Antineoplastic Agents
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Drug Carriers
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Prodrugs
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Polyethylene Glycols
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Copper
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Doxorubicin