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Science. 1989 Feb 17;243(4893):916-22.

Coordinate regulation and sensory transduction in the control of bacterial virulence.

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  • 1Department of Microbiology and Immunology, Stanford University, CA 94305.


Genes and operons that encode bacterial virulence factors are often subject to coordinate regulation. These regulatory systems are capable of responding to various environmental signals that may be encountered during the infectious cycle. For some pathogens, proteins that mediate sensory transduction and virulence control are similar to components of other bacterial information processing systems. Understanding the molecular mechanisms governing global regulation of pathogenicity is essential for understanding bacterial infectious diseases.

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