Assessment of knee joint pain in experimental rodent models of osteoarthritis

Methods Mol Biol. 2015:1226:175-81. doi: 10.1007/978-1-4939-1619-1_13.

Abstract

Pain assessment in animal models of osteoarthritis is integral to interpretation of a model's utility in representing the clinical condition, and enabling accurate translational medicine. Here we describe two methods for behavioral pain assessments available for use in animal models of experimental osteoarthritic pain: Von Frey filaments and spontaneous activity monitoring.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Arthritis, Experimental / physiopathology*
  • Humans
  • Mice
  • Osteoarthritis, Knee / physiopathology*
  • Pain Measurement / methods*