Abstract
A cDNA clone, which represents a species of mRNA that is expressed in growth-stimulated BALB/c-3T3 cells but not in resting cells, was found to encode a protein remarkably similar in sequence to the members of the immunoglobulin superfamily, especially to the extracellular portion of the mouse interleukin 1 receptor. The immunoglobulin superfamily is believed to be involved in cell adhesion and cell-to-cell interaction. The evidence that a member of this family is induced in the course of the initiation of cell proliferation is intriguing.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Cycle
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Cell Division
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Cells, Cultured
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Cloning, Molecular
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DNA / genetics*
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Genes, Immunoglobulin
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Immunoglobulins / genetics*
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Mice
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Mice, Inbred BALB C
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Molecular Sequence Data
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Multigene Family
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Proteins / genetics*
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RNA, Messenger / genetics
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Receptors, Immunologic / genetics*
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Receptors, Interleukin-1
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Sequence Homology, Nucleic Acid
Substances
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Immunoglobulins
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Proteins
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RNA, Messenger
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Receptors, Immunologic
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Receptors, Interleukin-1
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DNA