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Nature. 1989 Nov 30;342(6249):512-8.

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs.

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  • 1Tsukuba Science Center (RIKEN), Ibaraki, Japan.


The c-mos proto-oncogene product, pp39mos, is present in unfertilized Xenopus eggs, and disappears on fertilization. Microinjection of synthetic mos RNA into two-cell embryos induces cleavage arrest at metaphase. By contrast, egg cytosol extracts, when immunodepleted of endogenous pp39mos, lose their cleavage-arresting activity in injected embryos. These results demonstrate that Mos protein is the cytostatic factor CSF, long known as an endogenous meiotic inhibitor in vertebrate eggs.

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