Biochemistry of major human histocompatibility antigens

M J Owen; M J Crumpton

doi:10.1016/0167-5699(80)90048-1

Biochemistry of major human histocompatibility antigens

Immunol Today. 1980 Dec;1(6):117-22. doi: 10.1016/0167-5699(80)90048-1. Epub 2004 Aug 26.

Authors

M J Owen¹, M J Crumpton

Affiliation

¹ Imperial Cancer Research Fund Laboratories, P.O. Box No. 123, Lincoln's Inn Fields, London WC2A 3PX, UK.

PMID: 25290354
DOI: 10.1016/0167-5699(80)90048-1

Abstract

The major histocompatibility region, designated HLA in man and H-2 in the mouse, controls the expression of at least three groups of gene product - serum complement components and two sets of highly polymorphic cell-surface antigens, the so called histocompatibility antigens. In this review Michael Owen and Michael Crumpton describe some recent insights into the biochemical structure of HLA antigens.