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J Am Acad Dermatol. 1989 Sep;21(3 Pt 1):506-10.

Contact allergies in patients with familial benign chronic pemphigus (Hailey-Hailey disease)

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  • 1Department of Dermatology, Helsinki University Central Hospital, Finland.


To determine whether patients with familial benign chronic pemphigus have an increased risk for the development of contact allergies to topical therapy, we performed epicutaneous tests in 15 patients with this disease. Nine had positive patch test reactions of which seven were allergic to compounds used in local treatments. Allergic reactions in more than one patient were seen to neomycin sulfate (three patients), bacitracin (two), and hydrocortisone-17-butyrate and betamethasone-17-valerate (two). Although no comparable control group was similarly studied, the frequency of sensitization appears to be increased in patients with familial benign chronic pemphigus.

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