Biology of the extracellular matrix: an overview

J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S20-3. doi: 10.1097/IJG.0000000000000108.

Abstract

The extracellular matrix (ECM) is an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner. Components of the ECM link together to form a structurally stable composite, contributing to the mechanical properties of tissues. The ECM is also a reservoir of growth factors and bioactive molecules. It is a highly dynamic entity that is of vital importance, determining and controlling the most fundamental behaviors and characteristics of cells such as proliferation, adhesion, migration, polarity, differentiation, and apoptosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion
  • Cell Differentiation
  • Cell Movement
  • Cell Proliferation
  • Exfoliation Syndrome / metabolism*
  • Extracellular Matrix / physiology*
  • Extracellular Matrix Proteins / metabolism*
  • Humans
  • Signal Transduction / physiology

Substances

  • Extracellular Matrix Proteins