Bmi-1 regulates the migration and invasion of glioma cells through p16

Cell Biol Int. 2015 Mar;39(3):283-90. doi: 10.1002/cbin.10390. Epub 2014 Oct 8.

Abstract

Bmi-1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi-1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. These results show that Bmi-1 contributes to the motility of glioma cells by regulating the expression of p16.

Keywords: Bmi-1; glioma; invasion; migration; p16.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms / metabolism
  • Brain Neoplasms / pathology*
  • Cell Line, Tumor
  • Cell Movement
  • Cyclin-Dependent Kinase Inhibitor p16 / antagonists & inhibitors
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism*
  • Down-Regulation
  • Glioma / metabolism
  • Glioma / pathology*
  • Humans
  • Matrix Metalloproteinase 2 / metabolism
  • Neoplasm Invasiveness
  • Polycomb Repressive Complex 1 / antagonists & inhibitors
  • Polycomb Repressive Complex 1 / genetics
  • Polycomb Repressive Complex 1 / metabolism*
  • RNA Interference
  • RNA, Small Interfering / metabolism

Substances

  • BMI1 protein, human
  • Cyclin-Dependent Kinase Inhibitor p16
  • RNA, Small Interfering
  • Polycomb Repressive Complex 1
  • Matrix Metalloproteinase 2