Abstract
Bmi-1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi-1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. These results show that Bmi-1 contributes to the motility of glioma cells by regulating the expression of p16.
Keywords:
Bmi-1; glioma; invasion; migration; p16.
© 2014 International Federation for Cell Biology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Brain Neoplasms / metabolism
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Brain Neoplasms / pathology*
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Cell Line, Tumor
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Cell Movement
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Cyclin-Dependent Kinase Inhibitor p16 / antagonists & inhibitors
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Cyclin-Dependent Kinase Inhibitor p16 / genetics
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Cyclin-Dependent Kinase Inhibitor p16 / metabolism*
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Down-Regulation
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Glioma / metabolism
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Glioma / pathology*
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Humans
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Matrix Metalloproteinase 2 / metabolism
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Neoplasm Invasiveness
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Polycomb Repressive Complex 1 / antagonists & inhibitors
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Polycomb Repressive Complex 1 / genetics
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Polycomb Repressive Complex 1 / metabolism*
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RNA Interference
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RNA, Small Interfering / metabolism
Substances
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BMI1 protein, human
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Cyclin-Dependent Kinase Inhibitor p16
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RNA, Small Interfering
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Polycomb Repressive Complex 1
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Matrix Metalloproteinase 2