A new biflavonoid from Solanum dulcamara L. and investigation of anti-hyperglycaemic activity of its fruit extract

Nat Prod Res. 2015;29(4):308-14. doi: 10.1080/14786419.2014.928878. Epub 2014 Sep 18.

Abstract

A new biflavone, 6,2',3″,5″,4‴-pentahydroxy-3,7″-biflavone, has been isolated from the fruits of Solanum dulcamara L., in addition to two known compounds, β-sitosterol and stigmasterol. Their structures were established on the basis of UV, IR, 1D, 2D NMR and HR-ESI-MS spectroscopic methods. The anti-hyperglycaemic effect of S. dulcamara was investigated using diabetic rats. The anti-hyperglycaemic activity of the fruit extract of S. dulcamara was presented for the first time in this study.

Keywords: Solanum dulcamara; Solonaceae; anti-hyperglycaemic activity; biflavonoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biflavonoids / isolation & purification
  • Biflavonoids / pharmacology*
  • Blood Glucose
  • Diabetes Mellitus, Experimental / drug therapy*
  • Fruit / chemistry
  • Hypoglycemic Agents / isolation & purification
  • Hypoglycemic Agents / pharmacology*
  • Male
  • Mice, Inbred BALB C
  • Molecular Structure
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Rats
  • Rats, Wistar
  • Solanum / chemistry*
  • Toxicity Tests, Acute

Substances

  • Biflavonoids
  • Blood Glucose
  • Hypoglycemic Agents
  • Plant Extracts