Warning: The NCBI web site requires JavaScript to function. more...
Generate a file for use with external citation management software.
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142.
The retinoblastoma (Rb) antioncogene encodes a nuclear phosphoprotein, p105-Rb, that forms protein complexes with the adenovirus E1A and SV40 large T oncoproteins. A novel, aberrant Rb protein detected in J82 bladder carcinoma cells was not able to form a complex with E1A and was less stable than p105-Rb. By means of a rapid method for the detection of mutations in Rb mRNA, this defective Rb protein was observed to result from a single point mutation within a splice acceptor sequence in J82 genomic DNA. This mutation eliminates a single exon and 35 amino acids from its encoded protein product.
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on