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J Exp Med. 1989 Jan 1;169(1):363-8.

Cloning and characterization of a cDNA for a new mouse T cell growth factor (P40).

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  • 1Ludwig Institute for Cancer Research, Brussels, Belgium.


Recently, we described a murine helper T cell-derived molecule with T cell growth factor activity that is functionally and structurally distinct from IL-2, IL-4, and other known growth factors. This molecule, designated P40, was identified as a glycoprotein capable of supporting antigen-independent growth of certain helper T cell clones. Here, we report the cloning and expression of a cDNA for this new growth factor. The predicted mature protein is a cationic cysteine-rich polypeptide of 14 kD without significant homology to previously sequenced proteins.

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